apalutamide will lower the extent or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications which are CYP3A4 substrates may result in reduce publicity to those remedies.Codeine is from a gaggle of medicines termed